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Semax

Semax

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Semax: Neuroprotective and Cognitive Peptide

Semax is a synthetic peptide developed in Russia that has been widely studied for its neuroprotective and nootropic properties. This heptapeptide is an analog of adrenocorticotropic hormone (ACTH) but lacks hormonal activity, making it a promising candidate for various neurological and cognitive research applications.

Mechanism of Action
Semax is believed to exert its effects by modulating the brain’s dopaminergic and serotonergic systems. It influences neurotrophins like brain-derived neurotrophic factor (BDNF) and promotes neurogenesis, synaptic plasticity, and neuronal repair. Additionally, Semax has been shown to regulate stress-response pathways and protect neurons from oxidative stress and ischemic damage.

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Disclaimer: For Research Purposes Only

This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use in humans. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.

N-Acetyl Semax Amidate Description

N-Acetyl Semax Amidate is a stabilized synthetic peptide variant engineered through N-terminal acetylation and C-terminal amidation to resist enzymatic degradation and extend biological activity. This modification replaces the original peptide’s terminal carboxylic acid (-COOH) with an amide group (-NH₂), enhancing its stability. 

Structurally defined as Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂, it demonstrates prolonged half-life (~30 minutes longer than standard Semax) and increased neuroprotective efficacy, modulating neurotransmitters like serotonin and dopamine and upregulating BDNF expression. Preclinical studies highlight its potential in cognitive enhancement, neuroregeneration, and therapeutic applications for stroke or neurodegenerative disorders.

Semax Peptide Structure

PubChem CID:  9811102
Molecular Formula: C37H51N9O10S
Molecular Weight: 813.9 g/mol
Synonyms: 

  • Semax
  • 80714-61-0
  • ACTH (4-7), Pro-Gly-Pro-
  • MEHFPGP
  • Met-Glu-His-Phe-Pro-Gly-Pro

Research Areas:

  • Neuroprotection
  • Stroke Treatment
  • Cognitive Function
  • Alzheimer’s Disease
  • Stress Response
  • Immune and Vascular System Modulation

Source: PubChem

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