BPC-157

BPC-157 Description

BPC-157 is a synthetic 15-amino acid peptide derived from a protective protein found in human gastric juice. With the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, it exhibits stability against enzymatic degradation and gastric acidity. While not naturally occurring as an isolated fragment, its parent protein contributes to gastrointestinal protection and repair. The peptide exhibits multifaceted mechanisms, including tissue repair promotion via activation of growth hormone receptors and pathways like JAK2, which enhance collagen synthesis and fibroblast activity.

BPC-157 Peptide Structure

Molecular Formula: C62H98N15O22

Molecular Weight: 1419.5 g/mol

PubChem CID: 108101

Synonyms:

• A886440
• L-Valine, glycyl-L-a-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-a-aspartyl-L-a-aspartyl-L-alanylglycyl-L-leucyl- Acetate

Research Areas:

• Wound Healing
• Musculoskeletal Healing
• Angiogenesis
• Gastrointestinal Conditions
• Ocular Health

Source: PubChem

Lyophilized Peptides

These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.

Product Usage

This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals.

Scientific Reviewer

Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.

References

1. Seiwerth, S., Sikiric, P., Grabarević, Ž., Zoričić, I., Hanževački, M., Ljubanović, D., Ćorić, V., Konjevoda, P., Petek, M., Ručman, R., Turković, B., Perović, D., Mikus, D., Jandrijević, S., Medvidović, M., Tadić, T., Romac, B., Kos, J., Perić, J., & Kolega, Z. (1997). BPC 157’s effect on healing. Journal of Physiology-Paris, 91, 173-178. https://doi.org/10.1016/S0928-4257(97)89480-6.
2. Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Design, Development and Therapy, 9, 2485 – 2499. https://doi.org/10.2147/DDDT.S82030.
3. Šola, M., Skroza, N., Mangino, G., Škrtić, A., Seiwerth, S., & Sikiric, P. (2022). Do We Have a New Psoriasis Drug?. The FASEB Journal, 36. https://doi.org/10.1096/fasebj.2022.36.s1.r5345.
4. Seiwerth, S., Milavić, M., Vukojević, J., Gojkovic, S., Krezic, I., Vuletić, L., Pavlov, K., Petrovic, A., Sikirić, S., Vraneš, H., Prtorić, A., Zizek, H., Durasin, T., Dobrić, I., Starešinić, M., Štrbe, S., Knežević, M., Šola, M., Kokot, A., Sever, M., Lovrić, E., Škrtić, A., Blagaic, A., & Sikiric, P. (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.627533.
5. Chang, C., Tsai, W., Lin, M., Hsu, Y., & Pang, J. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.. Journal of applied physiology, 110 3, 774-80 . https://doi.org/10.1152/japplphysiol.00945.2010.
6. Chang, C., Tsai, W., Hsu, Y., & Pang, J. (2014). Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts. Molecules, 19, 19066 – 19077. https://doi.org/10.3390/molecules191119066.
7. Japjec, M., Pavlov, K., Petrović, A., Starešinić, M., Šebečić, B., Buljan, M., Vraneš, H., Giljanovic, A., Drmic, D., Japjec, M., Prtorić, A., Lovrić, E., Vuletić, B., Dobrić, I., Blagaić, B., Škrtić, A., Seiwerth, S., & Predrag, S. (2021). Stable Gastric Pentadecapeptide BPC 157 as a Therapy for the Disable Myotendinous Junctions in Rats. Biomedicines, 9. https://doi.org/10.3390/biomedicines9111547.
8. Šebečić, B., Nikolić, V., Sikiric, P., Seiwerth, S., Šoša, T., Patrlj, L., Grabarević, Ž., Ručman, R., Petek, M., Konjevoda, P., Jadrijević, S., Perović, D., & Šlaj, M. (1999). Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation.. Bone, 24 3, 195-202 . https://doi.org/10.1016/S8756-3282(98)00180-X.
9. Hsieh, M., Liu, H., Wang, C., Huang, H., Lin, Y., Ko, Y., Wang, J., Chang, V., & Pang, J. (2017). Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. Journal of Molecular Medicine, 95, 323-333. https://doi.org/10.1007/s00109-016-1488-y.
10. Hsieh, M., Lee, C., Chueh, H., Chang, G., Huang, H., Lin, Y., & Pang, J. (2020). Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway. Scientific Reports, 10. https://doi.org/10.1038/s41598-020-74022-y.
11. Brčić, L., Brčić, I., Starešinić, M., Novinščak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing.. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60 Suppl 7, 191-6 . https://doi.org/10.1135/CSS200911118.
12. Sikiric, P., Seiwerth, S., Grabarević, Ž., Petek, M., Ručman, R., Turković, B., Rotkvić, I., Jagić, V., Duvnjak, M., Miše, S., Djačić, S., Šeparović, J., Veljača, M., Sallmani, A., Banic, M., & Brkić, T. (1994). The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.. Life sciences, 54 5, PL63-8 . https://doi.org/10.1016/0024-3205(94)00796-9.
13. Park, J., Lee, H., Sikiric, P., & Hahm, K. (2020). BPC157 rescued NSAID-cytotoxicity via stabilizing intestinal permeability and enhancing cytoprotection.. Current pharmaceutical design. https://doi.org/10.2174/1381612826666200523180301.
14. Sikiric, P., Drmic, D., Sever, M., Klicek, R., Blagaic, A., Tvrdeić, A., Kralj, T., Kovac, K., Vukojević, J., Siroglavić, M., Gojkovic, S., Krezic, I., Pavlov, K., Rasic, D., Mirkovic, I., Kokot, A., Škrtić, A., & Seiwerth, S. (2020). Fistulas healing. Stable gastric pentadecapeptide BPC 157 therapy.. Current pharmaceutical design. https://doi.org/10.2174/1381612826666200424180139.
15. Sikiric, P., Seiwerth, S., Ručman, R., Turković, B., Rokotov, D., Brčić, L., Sever, M., Klicek, R., Radić, B., Drmic, D., Ilić, S., Kolenc, D., Stambolija, V., Zoričić, Z., Vrčić, H., & Šebečić, B. (2012). Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157.. Current medicinal chemistry, 19 1, 126-32 . https://doi.org/10.2174/092986712803414015.
16. Sikiric, P., Kokot, A., Kralj, T., Zlatar, M., Masnec, S., Lazić, R., Lončarić, K., Oroz, K., Sablić, M., Boljesic, M., Antunović, M., Sikirić, S., Štrbe, S., Stambolija, V., Orešković, B., Kavelj, I., Novosel, L., Zubcic, S., Krezic, I., Škrtić, A., Jurjević, I., Blagaić, B., Seiwerth, S., & Starešinić, M. (2023). Stable Gastric Pentadecapeptide BPC 157—Possible Novel Therapy of Glaucoma and Other Ocular Conditions. Pharmaceuticals, 16. https://doi.org/10.3390/ph16071052.
17. Zlatar, M., Kokot, A., Vuletić, L., Masnec, S., Kralj, T., Periša, M., Barišić, I., Radić, B., Milanović, K., Drmic, D., Seiwerth, S., & Sikiric, P. (2021). BPC 157 as a Therapy for Retinal Ischemia Induced by Retrobulbar Application of L-NAME in Rats. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.632295.
18. Masnec, S., Kokot, A., Zlatar, M., Kalauz, M., Radić, B., Klicek, R., Drmic, D., Lazić, R., Seiwerth, S., & Sikiric, P. (2015). Perforating Corneal Injury in Rat and Pentadecapeptide BPC 157. The FASEB Journal, 29. https://doi.org/10.1016/j.exer.2015.04.016.
19. Radevski, F., Peraic, P., Mašek, T., Starčević, K., Krezic, I., Pavlov, K., Drmic, D., Kralj, T., Seiwerth, S., Sikiric, P., & Kokot, A. (2019). Stable Gastric Pentadecapeptide BPC 157 in Rats Subjected to High Fructose (80%) Diet for One Month Counteracts Hypertension and Compromised Optic Disc Head Circulation and Following Atrophy. The FASEB Journal, 33. https://doi.org/10.1096/fasebj.2019.33.1_supplement.822.9.