KLOW (GHK-Cu / BPC-157 / TB-500 / KPV) Peptide Blend Description
This multi-peptide preparation unites four widely researched regenerative peptides into a single vial for investigations that probe complementary pathways of tissue repair, inflammation control, and remodeling.
GHK-Cu is best known for up-regulating wound-healing genes and driving collagen, elastin, and angiogenic growth-factor expression.
BPC-157 exhibits gastro-protective, tendon-/ligament-healing, and anti-inflammatory actions through modulation of nitric-oxide signaling, growth-factor receptors, and cytokine balance.
TB-500 enhances cell migration and angiogenesis primarily via actin‐sequestering and integrin-linked pathways.
KPV (Lys-Pro-Val), a naturally occurring tripeptide fragment of α-MSH, provides potent anti-inflammatory and antimicrobial effects without pigmentation changes. It works by blocking NF-κB activation, suppressing pro-inflammatory cytokines (IL-1β, TNFα, IL-8), and accelerating wound healing via nitric oxide pathways [1–8]. KPV’s dual role in calming inflammation and directly reducing microbial burden makes it especially attractive for models of gut inflammation, dermatology, and tissue repair.
When combined, researchers can examine potential synergy across copper-mediated extracellular-matrix activation (GHK-Cu), cytoprotective/anti-inflammatory signaling (BPC-157), actin-dependent cell-motility mechanisms (TB-500), and tripeptide-driven NF-κB inhibition and antimicrobial activity (KPV). Typical in-vitro or in-vivo models evaluate collagen deposition rates, angiogenic indices, inflammatory cytokine levels, antimicrobial defense, or recovery timelines after controlled soft-tissue injury.
This is an 80 mg lyophilized blend containing:
- 50 mg GHK-Cu
- 10 mg BPC-157
- 10 mg TB-500
- 10 mg KPV
Peptide Structures
GHK-Cu
- Sequence: Gly-His-Lys · Cu²⁺
- Molecular Formula: C₁₄H₂₄CuN₆O₄
- Molecular Weight: 403.9 g/mol
- PubChem CID: 378611
- CAS Number: 49557-75-7
- Synonyms: Copper peptide GHK, Cu-GHK, NSC 661251
BPC-157
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Formula: C₆₂H₉₈N₁₆O₂₂
- Molecular Weight: 1419.5 g/mol
- PubChem CID: 9941957
- CAS Number: 137525-51-0
- Synonyms: PL-14736, Body-Protection Compound-157, Bepecin
TB-500 (Thymosin-β4 fragment)
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
- Molecular Formula: C₃₈H₆₈N₁₀O₁₄
- Molecular Weight: 889.0 g/mol
- PubChem CID: 62707662
- CAS Number: 885340-08-9
- Synonyms: Thymosin-β4 fragment 17-23, TB-500 acetate, Ac-LKKTETQ
KPV
- Sequence: Lys-Pro-Val
- Molecular Formula: C₁₆H₂₉N₅O₄
- Molecular Weight: 359.44 g/mol
- PubChem CID: N/A
- CAS Number: N/A
- Synonyms: α-MSH fragment (11–13), Tripeptide KPV
Lyophilized Peptides
All four peptides are supplied in a freeze-dried, filler-free state to maximize stability and preserve chemical integrity during refrigerated or frozen storage. Reconstitute with sterile solvent immediately prior to experimental use and store aliquots at ≤ –20 °C to prevent repeated freeze–thaw cycles.
Scientific Reviewer
Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.
